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| Rodrigues,Patrícia A.; Morais,Selene M.; Souza,Carolina M.; Magalhães,Davi V.; Vieira,Ícaro G.P.; Andrade,Geanne M.; Rao,Vietla S.; Santos,Flávia A.. |
| Byrsonima sericea leaves are extensively used in folk medicine in Brazil against gastric disorders. This study investigated the chemical constituents of B. sericea leaf ethanolic extract (BSLE) and its potential gastroprotective activity, with its possible mechanism of the action using ethanol to induce gastric mucosal damage in mice. The phytochemical analysis was carried out to identify the active constituents present in the extract, and the HPLC analysis was performed for the identification of flavonoids. BSLE at oral doses of 125, 250 and 500 mg/kg markedly attenuated the ethanol-evoked gastric lesions by 53.2, 84.9 and 87.6 %, respectively. The BSLE (250 mg/kg) prevented the depletion of gastric mucus and gastric mucosal nonproteic-sulfhydryl groups,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antioxidant; Byrsonima sericea; Flavonoids; Gastroprotection; Mechanisms of action. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000100011 |
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| Farias,Davi F.; Cavalheiro,Mariana G.; Viana,Martônio P.; Queiroz,Vanessa A.; Rocha-Bezerra,Lady C.B.; Vasconcelos,Ilka M.; Morais,Selene M.; Carvalho,Ana F.U.. |
| This study assessed the toxicity of seed water extracts of 15 leguminous species upon Aedes aegypti larvae. A partial chemical and biochemical characterization of water extracts, as well as the assessment of their acute toxicity in mice, were performed. The extracts of Amburana cearensis, Anadenanthera macrocarpa, Dioclea megacarpa, Enterolobium contortisiliquum and Piptadenia moniliformis caused 100% of mortalit y after 1 to 3 h of exposure. They showed LC50 and LC90 values ranging from 0.43 ± 0.01 to 9.06 ± 0.12 mg/mL and from 0.71 ± 0.02 to 13.03 ± 0.15 mg/mL, respectively. Among the secondary metabolite constituents, the seed water extracts showed tannins, phenols, flavones, favonols, xanthones, saponins and alkaloids. The extracts also showed high... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aedes aegypti; Larvicidal compounds; Leguminous seeds; Water extracts. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000300006 |
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